Thiamine Metabolites and Dementia?
نویسندگان
چکیده
منابع مشابه
Thiamine deficiency in the Western diet and dementia risk.
In their recent systematic review, ter Borg et al. estimated that 50% of older (≥65 years) men and 39% of older women are failing to reach the estimated average requirement for thiamine. This is noteworthy, as thiamine has a unique role in brain physiology as an essential cofactor for glucose metabolism; it is especially important for normal cognitive function in the elderly; and thiamine insuf...
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BACKGROUND Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) is a critical coenzyme for glucose metabolism and significantly reduced in brain and blood samples of patients with Alzheimer's disease (AD). AIMS To explore the diagnostic value of the measurement of blood thiamine metabolites for AD. METH...
متن کاملDiagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by 11C-PiB PET scanning
AIM We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODS Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11C-PiB PET s...
متن کاملEffects of thiamine deficiency and thiamine administration on the thiamine diphosphate-dependent enzymes in rat liver.
The activities of pyruvate and 2-oxoglutarate dehydrogenases were determined by a spectrophotometric method according to Massey, that of transketolase deter mined by Racker's method. The values of enzyme activity as well as the thiamine contents in the preparations were compared with those of the animals whose deficiencies were restored by thiamine administration. The thiamine deprivation resul...
متن کاملThiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
BACKGROUND The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. METHODOLOGY/PRINCIPAL FINDINGS The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee camp. Women were enrolled during antenatal care and followed after delivery. Samples were collecte...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2016
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.11.044